This blog is in response to Dr Briffa's post here. as I keep having problems commenting on his blogs.

While 44ng/ml is sufficient to not only maximize uptake of calcium (>32ng/ml) and ensure maximum bone mineral density (>42ng/ml), pregnant and nursing mothers should be aware that in order to maximize the amount of vitamin D3 in human breast milk 6400iu/daily was found to be necessary to raise (>58ng/ml) at latitude 32.
This is detailed in the Taylor, Wagner and Hollis paper.
Vitamin D supplementation during lactation to support infant and mother.
Although 4000iu/daily met the mothers daily needs in full it left babies being born with lower 25(OH)D status than required for optimum calcium absorption

They also found DAILY use of supplements was required by pregnant and nursing mothers to ensure an even daily Vitamin D3 supply to the foetus & baby.
It makes virtually no measurable difference for everyone else if you supplement daily or weekly.

While Dr Briffa will not be lactating he may be interested seeing in the
Grassrootshealth chart showing disease incidence by 25(OH)D status.
this may encourage him to go just another 10ng/ml higher and a bit nearer to the natural level at which human breast milk flows replete with D3.

Although 5000iu cholecalciferol capsules are now available online in the UK may I remind readers these are cheaper from USA discount providers like IHERB providing you don't order more than £18 in any single order as you then have to pay VAT on import + £8 Post Office handling fee.
WAB666 Introductory discount code WAB666.

These recent papers make me think the recent move to encourage mothers to take the "official" prenatal Vitamins available will do little or nothing to reduce MS or other disease incidence.

Developmental vitamin D deficiency causes abnormal brain development

Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases

If we are going to ensure babies come into the world vitamin D replete then we have to ensure vitamin D is getting to the foetus and via breast milk to the baby. As Dr Briffa has discover getting anywhere near 55ng/ml requires a lot more vitamin D3 than is "officially" regarded as sufficient.

Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
the active form of vitamin D, 1,25-dihydroxyvitamin D, Calcitriol, enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).

In monocytes/macrophages, this occurs primarily in response to activation of TLR, that induce expression of the vitamin D receptor and localized synthesis of 1,25(OH)(2)D from precursor 25-hydroxyvitamin D(3) (25OHD) Calcidiol.

To clarify the relationship between vitamin D and innate immunity, we assessed changes in hCAP expression in vivo and ex vivo in human subjects attending a bone clinic.

Of these, 38% were vitamin D-insufficient (<75 nM 25OHD) and received supplementation with vitamin D (50,000 IU vitamin D(2) twice weekly for 5 wk). Only morons spend $185 on Drisdol Ergocaciferol when they can buy the same strength Vitamin D3 Cholecalciferol FOR $30 the form human use best, most efficiently and most reliably. I sometimes wonder if they use the synthetic form in the hope it is more likely to fail.

Baseline 25OHD status or vitamin D supplementation had no effect on circulating levels of hCAP.
Therefore, ex vivo changes in hCAP for each subject were assessed using peripheral blood monocytes cultured with 10% autologous serum.
Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p < 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p < 0.001).
Following treatment with 19 kDa, expression of hCAP:
1) correlated with 25OHD levels in serum culture supplements (R = 0.649, p < 0.001);
2) was significantly enhanced by exogenous 25OHD (5 nM); and
3) was significantly enhanced with serum from vivo vitamin D-supplemented patients.

These data suggest that a key role of vitamin D in innate immunity is to maintain localized production of antibacterial hCAP following TLR activation of monocytes.

Diabetes Vitamin D.

We know from articles such as this
Diabetes: Incidence of childhood type 1 diabetes: a worrying trend that there is an increase in incidence of Type One.

In an earlier blog Vitamin D Diabetes prevention I link to Frank Garland explaining the science showing the Type I incidence could largely be prevented if the vitamin D status of pregnant and nursing mothers and their offspring was brought up to the level that allows human breast milk to flow replete with vitamin D3.

But it isn't just the evidence in that video.
Since then The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland.
has shown that in those areas of Newfoundland where they get the least UVB reaching the ground


we find the greatest incidence of Type One Diabetes.


However the only way the general public will come to hear about the relation between Increased incidence of Type One Diabetes in Children with lowest levels of vitamin D is if the online forums dedicated to Diabetes information are prepared to carry it.

Diabetes Daily have once again banned me for mentioning that Vitamin D is associated with all forms of Diabetes. In this case the trigger was the research
Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: Whitehall II study.
Nephropal has a blog on the topic of adiponectins that shows What raises adiponectin levels?
resveratrol - wine, mulberry, cacao
calorie restriction
niacin
Vitamin D
and if we connect that with the fact that the risk of incident diabetes decreased by 11% for 1 microg/ml higher adiponectin levels, it should be obvious that anyone interested in reducing Diabetes Incidence would want to know how to raise vitamin D status safely, how to be sure you have a safe level of 25(OH)D, and where to obtain vitamin D and testing from as cheaply as possible.

But that kind of information is not welcome on a site that is dedicated to maintaining diabetes incidence and simply isn't interested in prevention at all. I just don't understand why they are so unwilling to allow people with diabetes to have access to this information.

I've learn't how to put PDF files online so I've put a copy of

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation and Hydroxylase Enzymology REINHOLD VIETH
here
At Slideshare

So you can all read it and look at the diagrams I think you will also be able to download it from that link as well. It's an important hypothesis as it explains why it is better to use daily, weekly supplements rather than rely on large doses at extended intervals.

While I don't want to put anyone off having a winter sun holiday in the tropics I think anyone considering doing this would be best advise to take a higher level of vitamin D3 before they go (rather than think I'm going to get plenty of sun next month so no need to supplement now) NOT TO USE any D3 supplements while they are on holiday (to avoid very high levels) and then to resume supplmenting on the last day of the holiday and continue using effective amounts when you get home.

This is to try to even out the level over the period.
Try to keep 25(OH)D level stable will prevent the need for fine tuning of the immune system and shorten the time where there is imbalance between activating (25- and 1a-hydroxylase) and the metabolizing (24-hydroxylase) enzymes.

At last a decent article on the Vitamin D prevents cancer issue.
Exposure to sun 'may help people with cancer survive'
Sunbathing warnings may have been too simplistic, say scientists By Jeremy Laurance, Health Editor

You will see I've commented below the article to enable people to take effective action.

Chronic Disease Incidence by 25(OH)D level

Vitamin D helps breast cancer treatment.

Effect of vitamin D supplementation on serum 25-hydroxy vitamin
D levels, joint pain, and fatigue in women starting adjuvant
letrozole treatment for breast cancer
Vitamin D deficiency and insufficiency may contribute to musculoskeletal symptoms and bone loss observed in women taking aromatase inhibitors (AIs).
This study was conducted to determine the prevalence of suboptimal vitamin D levels in women initiating adjuvant letrozole for breast cancer and to determine whether supplementation with 50,000 IU of vitamin D3 weekly could reduce musculoskeletal symptoms and fatigue in women who have suboptimal vitamin D levels.
Sixty women about to begin an adjuvant AI were enrolled. Baseline 25OHD levels were obtained, and women completed symptom questionnaires.
They were then started on letrozole, along with standard dose calcium and vitamin D.
Four weeks later, women with baseline 25OHD levels below =40ng/ml started additional vitamin D3 supplementation at 50,000 IU per week for 12 weeks.
25OHD levels were re-assessed at 4, 10, and 16 weeks; the questionnaires were repeated at weeks 4 and 16. At baseline, 63% of women exhibited vitamin D deficiency (<20 ng/ml) or insufficiency (20-31 ng/ml).
25OHD levels >40 ng/ml were achieved in all 42 subjects who received 12 weeks of supplementation with 50,000 IU vitamin D3 weekly, with no adverse effects.
After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026).
Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI.
Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias.

I was particularly pleased to see that these researchers used the MOST effective form of Vitamin D. Cholecalciferol. Other researchers should take note also of the fact that they used EFFECTIVE AMOUNTS 50,000iu/weekly for 12 weeks.

If in Kansas it takes roughly 7000iu/daily to get women with breast cancer to a level where their bodies have a reserve of D3 above their daily needs to deal with the inflammation and pain then it is probable that in the UK up to 10,000iu/daily may be required.

Skin Cancer/Sunscreen - the Dilemma

Statins mimic Vitamin D3.

Statins and vitamin d
commenting on this paper

Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins? Full text online.
This is likely to be the way the claimed clinical benefit of statins is achieved and may be the pleiotropic effect of rosuvastatin, decreasing mortality in patients with coronary artery disease.

But they still don't know the mechanism involved

This is a new listing on PUBMED and it's relevant here because it seems to me pointless taking a statin (with many obvious and dangerous side effects) that achieves it's magic by actually increasing your vitamin D3 status (by some mechanism as yet unidentified) when you can more cheaply and more effectively and without any side effects achieve the same effect (without any side effects) by taking Cholecalciferol Vitamin D3 by itself.

It is sheer madness (or the perverted logic of big Pharma) to make people take a drug that has potential for unpleasant side effects that works by mimicking a safe supplement that is cheap and doesn't produce side effects at the normal amounts most people reading this require.

Dietary Fats Omega-6 and Omega-3: Impact Your Inflammation Gene Machine

Dietary Fats Omega-6 and Omega-3: Impact Your Inflammation Gene MachineAlthough this isn't directly related to vitamin D3 there is a connection in that the best dietary sources of D3 are also good sources of omega 3 and it is reasonable to predict that omega 3 and vitamin D3 may work synergistally to produce improved anti inflammatory status.
It's also worth noting that point made here that Attention to the background diet is often a missing design element in supplementation studies, which is necessary to observe consistent changes in cellular fatty acid distribution.
When looking at vitamin D3 studies we have ultimately to consider the 25(OH)D status that was achieved and over what timescale the improved vitamin D status was maintained.
Given the variation in response to both oral intake and UVB exposure the only way to be sure of the 25(OH)D status is to measure it. Simply looking at oral intake or the amounts of D3 issued to people simply may not be reflected the the vitamin D3 status achieved.

Nephropal on Vitamin D.

There are some very clear illustrations in Nephropals blogs that help you understand the way Vitamin D is metabolized in the body and how it performs some of it's functions.

Nephropal on mineral-metabolism

Nephropal The leaky gut

Nephropal on Vitamin d

I should point out there are checks and balances and feedback loops that make what happens in practice somewhat more complicated but for a basic understanding this is a good place to start.

Vitamin D for the prevention and treatment of pancreatic cancer.

Vitamin D for the prevention and treatment of pancreatic cancer.
Pancreatic cancer is ranked fifth among cancer-related deaths worldwide with a 5-year survival rate of less than 5%.
Currently, surgery is the only effective therapy.
However, most patients are diagnosed in the late stage and are not suitable for receiving curative surgery.
Moreover, pancreatic cancer doesn't respond well to traditional chemotherapy and radiotherapy, leaving little effective treatment for advanced pancreatic cancer cases.
1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], the biologically active form of vitamin D(3), was originally identified during studies of calcium and bone metabolism, though it is now recognized that it exerts biological effects in almost every tissue in the body.
Abundant evidence has shown that 1alpha,25(OH)(2)D(3) has antiproliferative, apoptotic, pro-differentiation and antiangiogensis effects in many types of cancer cells in vivo and in vitro, including breast, prostate, and colon.
Similarly, the antitumor growth effect of 1alpha,25(OH)(2)D(3) on pancreatic cells has been demonstrated.
The clinical use of 1alpha,25(OH)(2)D(3) is impeded by the lethal side effects of hypercalcemia and hypercalciuria.
Therefore, 1alpha,25(OH)(2)D(3) analogs, which are either equipotent or more potent than 1alpha,25(OH)(2)D(3) in inhibiting tumor cell growth but with fewer hypercalcemic and hypercalciuric side effects, have been developed for the treatment of different cancers.
Recently, a pre-clinical study demonstrated that a less calcemic analog of 1alpha,25(OH)(2)D(3), 19-nor-1alpha,25(OH)(2)D(2) (Paricalcitol), is effective in inhibiting tumor growth in vitro and in vivo, via upregulation of p21 and p27 tumor suppressor genes.
Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway. 1alpha,25(OH)(2)D(3) and its analogs are potentially attractive novel therapies for pancreatic cancer.

It may be helpful to for those who are concerned about the possibility of the hypercalcemic and hypercalciuric adverse potential to read Vieth Paper Vitamin D and cancer mini-symposium: the risk of additional vitamin D. the abstract of which states
Any benefit of vitamin D needs to be balanced against the risk of toxicity, which is characterized by hypercalcemia.
Daily brief, suberythemal exposure of a substantial area of the skin to ultraviolet light, climate allowing, provides adults with a safe, physiologic amount of vitamin D, equivalent to an oral intake of about 10,000 IU vitamin D(3) per day, with the plasma 25-hydroxyvitamin D (25(OH)D) concentration potentially reaching 220 nmol/L (88 ng/mL).
The incremental consumption of 40 IU/d of vitamin D(3) raises plasma 25(OH)D by about 1 nmol/L (0.4 ng/mL).
High doses of vitamin D may cause hypercalcemia once the 25(OH)D concentration is well above the top of the physiologic range.
The physiological buffer for vitamin D safety is the capacity of plasma vitamin D-binding protein to bind the total of circulating 25(OH)D, vitamin D, and 1,25-dihydroxyvitamin D [1,25(OH)2D].
Hypercalcemia occurs when the free concentration is inappropriately high because vitamin D and its other metabolites have displaced 1,25(OH)2D from vitamin D-binding protein.
Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000 IU/d of vitamin D(3) poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

For anyone with a cancer diagnosis Dr Cannell of The Vitamin D Council has an interesting newsletter on the subject Does Vitamin D Treat Cancer.
Far better though is prevention and this is covered in this newsletter from the same source.

Magnesium Vitamin D

Is it important to take magnesium with vitamin D?
This comes from Dr Cannell's July newsletter.

Judith, New York

Dear Judith:

Yes, it is important to have adequate magnesium intake and most Americans do not. A number of people have written about muscle cramps after they start sunbathing or taking Vitamin D. This is likely caused from the neuromuscular hyperexcitability of magnesium deficiency that is somehow unmasked by higher Vitamin D levels.

Abbott LG, Rude RK. Clinical manifestations of magnesium deficiency. Miner Electrolyte Metab. 1993;19(4-5):314-22.

The latest survey of magnesium (Mg) intakes of Americans (NHANES) indicates the majority of Americans have Mg intakes below the recommended Daily Allowance (RDA) in all age and race groups tested. In fact, the daily intakes were: 70 mg/day less than recommended in Caucasian men; 130 mg/day less in African American men; 60 mg/day less in Caucasian women; and 120 mg/day less than recommended in African American women. (The RDA in 320 mg/day for women and 420 mg/day for men.) Also, one statistic called the standard error of the mean was quite low, for example, +/- 6 for Caucasian men, raising the possibility that the vast majority of Americans are Mg deficient.

Even more interesting were some of the top ten contributors for American Mg intake: coffee, 3.7% of intake; milk, 2.2 %; beer, 1.8%; French fries, 1.1%. Not a word about Americans eating many seeds and nuts, the foods loaded with Mg. Dr. Earl Ford of the CDC, the lead author, concluded, “”Because magnesium has many potential health benefits, increasing the dietary intake of magnesium in the U.S. population should be an important public health goal.”

Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of US adults. J Nutr. 2003 Sep;133(9):2879-82.

Apparently, Mg is better absorbed from foods than from supplements and Mg absorption varies with the degree of Mg deficiency. Mg is at the heart of the chlorophyll molecule, which is why green vegetables are a good Mg source. Other good sources are nuts, seeds, whole grains, dried fruit, and some fish. The richest source by far on a per gram basis is dried seeds, like pumpkin, sunflower, and sesame seeds, containing between 340 to 535 mg per 100 gram serving. High Mg foods were probably staples of Paleolithic man.

Magnesium. Office of Dietary Supplements • NIH Clinical Center • National Institutes of Health

Magnesium (Mg) is the forgotten mineral, an orphan as Professor Robert Heaney of Creighton University says. It is the fourth most abundant mineral in the body, is involved in more than 300 biochemical reactions. All the enzymes that metabolize Vitamin D require Mg. It is also required in each of the steps concerned with replication, transcription, and translation of genetic information, and thus it is also needed for the genetic mechanism of action of Vitamin D.

Zofková I, Kancheva RL. The relationship between magnesium and calciotropic hormones. Magnes Res. 1995 Mar;8(1):77-84.

Carpenter TO. Disturbances of vitamin D metabolism and action during clinical and experimental magnesium deficiency. Magnes Res. 1988 Dec;1(3-4):131-9.

Besides these two reviews, any scientist interested in Vitamin D and the immune system should read:

McCoy H, Kenney MA. Interactions between magnesium and vitamin D: possible implications in the immune system. Magnes Res. 1996 Oct;9(3):185-203.

Two interesting cases of Mg dependent Vitamin D-resistant rickets appeared in the Lancet in 1974. Two children, one age two and the other age five, presented with classic rickets. 600,000 IU of Vitamin D daily for ten days did not result in any improvement in six weeks, in either x-rays or alkaline phosphatase, and the doctors diagnosed Vitamin D resistant rickets. Almost by accident, serum Mg levels were then obtained, which were low in both children. After the treatment with Mg, the rickets rapidly resolved.

Reddy V, Sivakumar B. Magnesium-dependent vitamin-D-resistant rickets. Lancet. 1974 May 18;1(7864):963-5.

What does that mean? How can one treat rickets with Mg? Remember, these children took a total of 6 million units, that’s a total of 6,000,000 IU of vitamin D over ten days (it was given as injections so we know the children actually took it), thus they had plenty of vitamin D but, in their cases, the vitamin D needed Mg to work.

In 1976, Dr. Ramon Medalle and colleagues at the Washington University School of Medicine described five patients with Mg deficiency and low blood calcium whose calcium blood levels would not return to normal after Vitamin D treatment, a condition known as Vitamin D resistance. However, serum calcium promptly returned to normal in all five patients after treatment with Mg, raising the possibility that such Vitamin D resistance may be caused from simple, but severe, Mg deficiency.

Medalle R, Waterhouse C, Hahn TJ. Vitamin D resistance in magnesium deficiency. Am J Clin Nutr. 1976 Aug;29(8):854-8.

What is not known is how mild to moderate Mg deficiencies, like most Americans apparently have, affect Vitamin D metabolism. The safe thing to do is to eat green leafy vegetables and a handful of sunflower seeds every day (trader Joe’s sells a variety of seeds). If you can’t, won’t, or don’t end up doing that, then take a Vitamin D supplement with added Mg. Bio Tech Pharmacal now sells such a supplement, Vitamin D3 Plus, and will make a contribution of one dollar to the Council for every bottle sold. Bio Tech’s phone number: (479) 443-9148

Bio Tech’s new Vitamin D3 Plus formula also contains zinc (the base of the fingers of the Vitamin D Receptor each contains a zinc molecule), Vitamin K2 (Vitamin K helps direct Vitamin D to calcify the proper organs and prevents calcification of improper organs), boron (boron is involved in the rapid, non-genomic action of Vitamin D on the cell wall), a small amount of genestein (about one-half the amount the average Japanese consumes every day), which helps activated Vitamin D stay around longer at the receptor site, and a tiny amount of Vitamin A. Again, the wisest thing to do is to eat green leafy vegetables and a handful of seeds every day as that combination contains the co-factors Vitamin D needs, the co-factors many Americans are deficient in.
John Cannell, MD
Vitamin D Council

If you are interested in learning more about magnesium then Dr Davis of the Heartscanblog has written several blogs on the topic.

Krispin has some interesting points to make in her Magnesium Update

Dr BG AnimalPharm has also done a blog on magnesium

Mrs Doubtfire at Neurotalk also has sound advice on magnesium supplements.

I started using Magnesium Malate as suggested by Dr McCleary Brain Trust Program.
I've also tried the more expensive Magnesium Chelate If you decide to use either of these and haven't used Iherb before don't forget the $5 discount code WAB666 and when you get your rewards code please be generous with it. The more people who use it the more discounts will accrue to your next order. Maintaining a safe vitamin D magnesium status is a long term investment in your health so you will be needing to keep this up.

Vitamin D Toxicity

"Vitamin D and cancer mini-symposium: the risk of additional vitamin D."
this paper by Vieth R explains that in practice it has been shown intakes of below 10,000iu/daily for adults are absolutely safe.

"Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000 IU/d of vitamin D(3) poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D."

It generally takes prolonged (many months) intake of more than 40,000iu/daily before levels above 150ng/mL are reached and the possibility of adverse events is significant. Indeed it may be that 200ng is the level where adverse events are recorded.

However, most readers here can take comfort from the fact that Dr Davis of the Heartscanblog has shown in his Wisconsin Practice for Heart Patients that intakes of 5000iu usually are sufficient for most of his female patients and 6000iu for males. However, he does point out that there is a huge variation in the efficiency at which we absorb and use D3 so regular 25(OH)D testing is a good idea to confirm you are always in the region of 55ng 137.5nmol/l at which human breast milk flows replete with D3, peak muscle performance is achievable and is the level associated with the least incidence of chronic conditions such as Diabetes, cancer, heart disease, MS,

Grassrootshealth D Action Campaign
Grassrootshealth are a charity promoting knowledge of the latest Vitamin D3 research. As part of their work they are running a trial monitoring 25(OH)D status against hospital interventions.
If you participate in this trial you can have your 25(OH)D checked up to twice yearly for $40 a time, roughly £24. It's a simple finger prick, 2 drops of blood on a test strip that you return in the post and they send you a link to your results.
Because of the difficulty in getting optimal amounts of vitamin D from sun exposure and adequate amounts from diet it's really worth participating in this trial.

When buying vitamin D3 you may want to consider the form Vitamin D3 Plus suggested by Dr Cannell of the Vitamin D Council

However, I've always found the standard vitamin D3 capsules Biotech Pharmacal produce are fine for me. When buying from Bio Tech if your order is likely to cost more than £18 to the UK it may be worth phoning your order through as you can then ask for the customs label declaration to state the wholesale rather than retail value, to avoid the excessive £8 UK Post Office handling fee for collecting the £3 customs duty.

As Vitamin D3 supplementation is a long term commitment it is worth using the cheapest source. I find these Now Foods, Vitamin D-3, Highest Potency, 5,000 IU, 120 Softgels absolutely fine.
The postage IHERB charge is generally less than elsewhere and by using the Rewards code WAB666 you can save $5 and by spreading the rewards code you will be given when you have ordered you can get further discounts from subsequent orders.

What's a Vitamin D deficiency

How Vitamin D Reduces Incidence of Cancer:

How Vitamin D Reduces Incidence of Cancer:

Dr. Garland's DINOMIT Model: Vitamin D for Cancer Prevention (PDF)

Vitamin D and Cancer Prevention. Garland

Dose-Response of Vitamin D and a Mechanism for Cancer Prevention

The slides used in the above video can be downloaded from this link.
Dose-Response of Vitamin D and a Mechanism for Prevention of Cancer
by Cedric F. Garland, Dr.P.H., Edward D. Gorham, M.P.H., Ph.D., Sharif B. Mohr, M.P.H., and Frank C. Garland, Ph.D.

Can vitamin D help prevent certain cancers and other diseases such as type 1 diabetes, cardiovascular disease, and certain autoimmune and chronic diseases? To answer these questions and more, UCSD School of Medicine and GrassrootsHealth bring you this innovative series on vitamin D deficiency. Join nationally recognized experts as they discuss the latest research and its implications. In this program, Edward Gorham, PhD, discusses the dilemma of skin cancer and sunscreen use.

Grassrootshealth D Action provide 25(OH)D testing at cost price.

Bio Tech Pharmacal offer cheap Dry Powder filled capsules of Cholecalciferol and are the only source of 50,000iu capsules I know of.
Now Foods, Vitamin D-3, Highest Potency, 5,000 IU, 120 Softgels Iherb is the cheapest source of 5000iu oilbased gel caps. Use Code WAB666 for a $5 introductory discount and try to share your rewards code when you have an IHERB account as the more you share the more discounts you get yourself.

Vitamin D and Cardiovascular Disease

Vitamin D Diabetes prevention

Allow plenty of time to watch this video.
It comes from the Grassrootshealth.org and you may find it helpful, if you want to study the graphs in more detail to download the slides separately

Vitamin D Prevents Cancer: Is It True?