Sunday, 24 March 2013

Saturday, 20 October 2012

No Risk of Calcium Overload with Mega Vitamin D


No Risk of Calcium Overload with Mega Vitamin D

PHILADELPHIA -- There were no toxic levels of calcium in patients taking high-doses of vitamin D, a small retrospective study showed.
A total of 121 patients without kidney or liver dysfunction taking high-dose vitamin D (2,000 to 7,000 IU/day) also had their calcium blood levels assessed over 4 years, according to Neena E. Thomas-Eapen, MD, of the University of North Dakota Center for Family Medicine in Minot, N.D., and colleagues.
None of these patients had hypercalcemia, defined as a calcium level greater than 10.5 mg/dL, Thomas-Eapen reported here at the annual meeting of the American Academy of Family Physicians.
"We want physicians to know that if there is a need for vitamin D supplementation, which is very important for bones, the brain, the endocrine and the immunological systems, they should feel free to use a few thousand international units to 7,000 international units of vitamin D safely in patients with normal liver and kidney functions," Thomas-Eapen told MedPage Today.
"I mostly use a standard of 2,000 international units daily, but sometimes between 2,000 to 7,000 international units," she said.
"I had not seen hypercalcemia in practice in patients with higher doses of vitamin D, but I wanted to conduct this study to quantify the data," she said.
The literature says that higher doses of vitamin D cause hypercalcemia. And the Institute of Medicine in 2010 recommended maximum vitamin D levels of between 1,000 to 4,000 IU per day.
"But in practice, I have seen that sometimes we need a higher dosage to bring up those levels, particularly in patients with osteoporosis or osteopenia," she said.
Thomas-Eapen and colleagues retrospectively reviewed patient charts and found 121 with both vitamin D and calcium levels recorded between 2008 and 2011.
Patients ranged in age from 30 to 90 and all patients had a minimum calcium intake of about 1,000 mg daily from all sources.
Vitamin D dosage ranged from 800 to 7,000 IU daily. As the level of vitamin D increased, so did the level of calcium, but it never breached the 9.5 mg/dL mark.
For the year 2008, the mean level of calcium for vitamin D levels of less than 1,000 IU was 9.1 mg/dL. That rose to 9.2 for vitamin D levels between 1,001 and 2,000 IU and 9.4 for vitamin D levels between 2,001 and 3,000 IU. But when vitamin D levels were 3,000 and above, the calcium levels remained at 9.5. These figures remained steady for each year of the study.
Thomas-Eapen said that she had previously reported that none of these patients developed kidney stones.
"On a practical basis, physicians should feel comfortable using a higher dose of vitamin D as the clinical situation indicates, but they should also check vitamin D and calcium levels in the winter," she concluded.
The study was limited by its retrospective nature and small size, Thomas-Eapen said. She added that a multicenter study with a larger sample size and longer duration would be useful to confirm these results.
Thomas-Eapen reported she has no conflicts of interest.
Primary source: American Academy of Family Physicians

Tuesday, 10 July 2012

City Assays Vitamin D Blood Spot Test
How much does it cost? 
Orders for kits after 1st April 2012: £25 to UK/Ireland and £30 Overseas Bulk Orders after 1st April 2012: We offer a discount for orders of 10 or more kits, paid by card at the time of order (£20 UK/Ireland and £25 Overseas).

I've used these people and their service is fine.
You order the kits by phone.
They arrive by first class post pretty quickly. I ordered Friday, (late afternoon 4.30pm) and they arrived Tuesday.
You drop blood spots onto test strip and fill in your email address and details. Return in reply envelope.
 They email the result in a 2~3 of days after they receive the sample back.

 If anyone wants to use the surplus kits (I ordered 10) then please email me your address and I'll be happy to post them to you at COST PRICE plus the cost of postage.
They aren't very heavy so large letter postage rate is all that's required.
My email is swabymanor@googlemail.com

Monday, 17 May 2010

As we know that naturally human skin generates between 10.000~20,000iu vitamin D3 given full body non burning sun/uvb exposure it is a reasonable assumption that amounts under the level naturally acquired should be within the capacity of our DNA to manage safely.

5000iu ~10,000iu Vitamin D3 supplements are cheaply and easily obtained from the USA.
Grassrootshealth Banner shows most people can attain and maintain a 25(OH)D level around 60ng/ml ~ 150nmol/l with 6000iu/daily D3.

I maintain my 25(OH)D at 64ng/ml with 5000iu/daily + regular full body sun/uvb exposures.

I have put a copy of Vieth's paper
How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation and Hydroxylase Enzymology
online as understanding the importance of keeping a HIGH but STABLE 25(OH)D is extremely important.

One of the main objections to using Ergocalciferol is it's potential for speeding up the catabolism of vitamin D as shown in Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans

Comparison of Daily, Weekly, and Monthly Vitamin D3 in Ethanol Dosing Protocols for Two Months in Elderly Hip Fracture Patients This paper shows that there was little difference in the results of the different regimes however they were only seeking to raise 25(OH)D to 30 ng/ml (75 nmol/liter) and as some people don't achieve optimum bone mineral density until 44ng/ml that is too low a level for safety. Similarly human only store D3 when daily needs for Vitamin D have been met and we only start to have significant D3 reserves when 25(OH)D is above 50ng/ml and Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation shows Vitamin D3 replete human breast milk is only available approaching 60ng/ml, the level human bodies naturally attain and maintain living near naked outdoor lives. (60~80ng/ml)

So if daily supplementation and/or regular sun/uvb exposure isn't practicable the nearest equivalent regime to daily would be weekly usage of 50,000iu.
Fortnightly use of 100,000iu or 200,000iu every 28 days.

Biotech pharmacal supply 50,000iu dry powder filled capsules. If you are buying for your personal use then PHONE your order using one of the cheap prefix call rates (1899 ~ 18185) remembering the time difference and ask for the Wholesale order value to be declared on the outer label. Otherwise you get stung for Tax and £8 Post office handling charge.

For best results these should be taken with the largest meal of the day ideally with butter, or coconut oil. Vitamin D3 is a fat soluble vitamin.

Ideally daily supplement use will keep levels most stable and it's relatively easy to catch up if you miss a day or so.
These are what I use.
Country Life, Vitamin D3, 5,000 IU, 200 Softgels"

I prefer Medium Chain Triglyceride oil as the carrier, it's easily and quickly metabolized and because it encourages fat burning is helpful for weight loss and improved mitochondrial function.

I do not recommend omega 6 oil based vitamin D capsules, There is too much omega in the diet so adding supplemental sources only makes matters worse.
The fish oil based D3 are fine but expensive and the amount of omega 3 they provide is so small as to be insignificant for the extra cost involved.
There are some in olive oil that work out a cheap option but it's not a huge saving and the MCT is far less likely to go rancid as MCT is extremely stable and has a 2 yr shelf life.

I've provided examples from IHERB as their $4 shipping to the UK is cheapest(allow 10 days). $5 discount code WAB666. UK readers keep order value below £18 or pay take + £8 handling charge. USA/Canadian readers may find Amazon/Swanson's/Vitacost etc cheaper depending on local shipping charges.

Thursday, 17 December 2009

This blog is in response to Dr Briffa's post here. as I keep having problems commenting on his blogs.

While 44ng/ml is sufficient to not only maximize uptake of calcium (>32ng/ml) and ensure maximum bone mineral density (>42ng/ml), pregnant and nursing mothers should be aware that in order to maximize the amount of vitamin D3 in human breast milk 6400iu/daily was found to be necessary to raise (>58ng/ml) at latitude 32.
This is detailed in the Taylor, Wagner and Hollis paper.
Vitamin D supplementation during lactation to support infant and mother.
Although 4000iu/daily met the mothers daily needs in full it left babies being born with lower 25(OH)D status than required for optimum calcium absorption

They also found DAILY use of supplements was required by pregnant and nursing mothers to ensure an even daily Vitamin D3 supply to the foetus & baby.
It makes virtually no measurable difference for everyone else if you supplement daily or weekly.

While Dr Briffa will not be lactating he may be interested seeing in the
Grassrootshealth chart showing disease incidence by 25(OH)D status.
this may encourage him to go just another 10ng/ml higher and a bit nearer to the natural level at which human breast milk flows replete with D3.

Although 5000iu cholecalciferol capsules are now available online in the UK may I remind readers these are cheaper from USA discount providers like IHERB providing you don't order more than £18 in any single order as you then have to pay VAT on import + £8 Post Office handling fee.
WAB666 Introductory discount code WAB666.

These recent papers make me think the recent move to encourage mothers to take the "official" prenatal Vitamins available will do little or nothing to reduce MS or other disease incidence.

Developmental vitamin D de´Čüciency causes abnormal brain development

Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases

If we are going to ensure babies come into the world vitamin D replete then we have to ensure vitamin D is getting to the foetus and via breast milk to the baby. As Dr Briffa has discover getting anywhere near 55ng/ml requires a lot more vitamin D3 than is "officially" regarded as sufficient.

Wednesday, 4 November 2009

Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
the active form of vitamin D, 1,25-dihydroxyvitamin D, Calcitriol, enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).

In monocytes/macrophages, this occurs primarily in response to activation of TLR, that induce expression of the vitamin D receptor and localized synthesis of 1,25(OH)(2)D from precursor 25-hydroxyvitamin D(3) (25OHD) Calcidiol.

To clarify the relationship between vitamin D and innate immunity, we assessed changes in hCAP expression in vivo and ex vivo in human subjects attending a bone clinic.

Of these, 38% were vitamin D-insufficient (<75 nM 25OHD) and received supplementation with vitamin D (50,000 IU vitamin D(2) twice weekly for 5 wk). Only morons spend $185 on Drisdol Ergocaciferol when they can buy the same strength Vitamin D3 Cholecalciferol FOR $30 the form human use best, most efficiently and most reliably. I sometimes wonder if they use the synthetic form in the hope it is more likely to fail.

Baseline 25OHD status or vitamin D supplementation had no effect on circulating levels of hCAP.
Therefore, ex vivo changes in hCAP for each subject were assessed using peripheral blood monocytes cultured with 10% autologous serum.
Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p < 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p < 0.001).
Following treatment with 19 kDa, expression of hCAP:
1) correlated with 25OHD levels in serum culture supplements (R = 0.649, p < 0.001);
2) was significantly enhanced by exogenous 25OHD (5 nM); and
3) was significantly enhanced with serum from vivo vitamin D-supplemented patients.

These data suggest that a key role of vitamin D in innate immunity is to maintain localized production of antibacterial hCAP following TLR activation of monocytes.