Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
the active form of vitamin D, 1,25-dihydroxyvitamin D, Calcitriol, enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).

In monocytes/macrophages, this occurs primarily in response to activation of TLR, that induce expression of the vitamin D receptor and localized synthesis of 1,25(OH)(2)D from precursor 25-hydroxyvitamin D(3) (25OHD) Calcidiol.

To clarify the relationship between vitamin D and innate immunity, we assessed changes in hCAP expression in vivo and ex vivo in human subjects attending a bone clinic.

Of these, 38% were vitamin D-insufficient (<75 nM 25OHD) and received supplementation with vitamin D (50,000 IU vitamin D(2) twice weekly for 5 wk). Only morons spend $185 on Drisdol Ergocaciferol when they can buy the same strength Vitamin D3 Cholecalciferol FOR $30 the form human use best, most efficiently and most reliably. I sometimes wonder if they use the synthetic form in the hope it is more likely to fail.

Baseline 25OHD status or vitamin D supplementation had no effect on circulating levels of hCAP.
Therefore, ex vivo changes in hCAP for each subject were assessed using peripheral blood monocytes cultured with 10% autologous serum.
Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p < 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p < 0.001).
Following treatment with 19 kDa, expression of hCAP:
1) correlated with 25OHD levels in serum culture supplements (R = 0.649, p < 0.001);
2) was significantly enhanced by exogenous 25OHD (5 nM); and
3) was significantly enhanced with serum from vivo vitamin D-supplemented patients.

These data suggest that a key role of vitamin D in innate immunity is to maintain localized production of antibacterial hCAP following TLR activation of monocytes.

Diabetes Vitamin D.

We know from articles such as this
Diabetes: Incidence of childhood type 1 diabetes: a worrying trend that there is an increase in incidence of Type One.

In an earlier blog Vitamin D Diabetes prevention I link to Frank Garland explaining the science showing the Type I incidence could largely be prevented if the vitamin D status of pregnant and nursing mothers and their offspring was brought up to the level that allows human breast milk to flow replete with vitamin D3.

But it isn't just the evidence in that video.
Since then The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland.
has shown that in those areas of Newfoundland where they get the least UVB reaching the ground


we find the greatest incidence of Type One Diabetes.


However the only way the general public will come to hear about the relation between Increased incidence of Type One Diabetes in Children with lowest levels of vitamin D is if the online forums dedicated to Diabetes information are prepared to carry it.

Diabetes Daily have once again banned me for mentioning that Vitamin D is associated with all forms of Diabetes. In this case the trigger was the research
Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: Whitehall II study.
Nephropal has a blog on the topic of adiponectins that shows What raises adiponectin levels?
resveratrol - wine, mulberry, cacao
calorie restriction
niacin
Vitamin D
and if we connect that with the fact that the risk of incident diabetes decreased by 11% for 1 microg/ml higher adiponectin levels, it should be obvious that anyone interested in reducing Diabetes Incidence would want to know how to raise vitamin D status safely, how to be sure you have a safe level of 25(OH)D, and where to obtain vitamin D and testing from as cheaply as possible.

But that kind of information is not welcome on a site that is dedicated to maintaining diabetes incidence and simply isn't interested in prevention at all. I just don't understand why they are so unwilling to allow people with diabetes to have access to this information.

I've learn't how to put PDF files online so I've put a copy of

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation and Hydroxylase Enzymology REINHOLD VIETH
here
At Slideshare

So you can all read it and look at the diagrams I think you will also be able to download it from that link as well. It's an important hypothesis as it explains why it is better to use daily, weekly supplements rather than rely on large doses at extended intervals.

While I don't want to put anyone off having a winter sun holiday in the tropics I think anyone considering doing this would be best advise to take a higher level of vitamin D3 before they go (rather than think I'm going to get plenty of sun next month so no need to supplement now) NOT TO USE any D3 supplements while they are on holiday (to avoid very high levels) and then to resume supplmenting on the last day of the holiday and continue using effective amounts when you get home.

This is to try to even out the level over the period.
Try to keep 25(OH)D level stable will prevent the need for fine tuning of the immune system and shorten the time where there is imbalance between activating (25- and 1a-hydroxylase) and the metabolizing (24-hydroxylase) enzymes.

At last a decent article on the Vitamin D prevents cancer issue.
Exposure to sun 'may help people with cancer survive'
Sunbathing warnings may have been too simplistic, say scientists By Jeremy Laurance, Health Editor

You will see I've commented below the article to enable people to take effective action.

Chronic Disease Incidence by 25(OH)D level

Vitamin D helps breast cancer treatment.

Effect of vitamin D supplementation on serum 25-hydroxy vitamin
D levels, joint pain, and fatigue in women starting adjuvant
letrozole treatment for breast cancer
Vitamin D deficiency and insufficiency may contribute to musculoskeletal symptoms and bone loss observed in women taking aromatase inhibitors (AIs).
This study was conducted to determine the prevalence of suboptimal vitamin D levels in women initiating adjuvant letrozole for breast cancer and to determine whether supplementation with 50,000 IU of vitamin D3 weekly could reduce musculoskeletal symptoms and fatigue in women who have suboptimal vitamin D levels.
Sixty women about to begin an adjuvant AI were enrolled. Baseline 25OHD levels were obtained, and women completed symptom questionnaires.
They were then started on letrozole, along with standard dose calcium and vitamin D.
Four weeks later, women with baseline 25OHD levels below =40ng/ml started additional vitamin D3 supplementation at 50,000 IU per week for 12 weeks.
25OHD levels were re-assessed at 4, 10, and 16 weeks; the questionnaires were repeated at weeks 4 and 16. At baseline, 63% of women exhibited vitamin D deficiency (<20 ng/ml) or insufficiency (20-31 ng/ml).
25OHD levels >40 ng/ml were achieved in all 42 subjects who received 12 weeks of supplementation with 50,000 IU vitamin D3 weekly, with no adverse effects.
After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026).
Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI.
Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias.

I was particularly pleased to see that these researchers used the MOST effective form of Vitamin D. Cholecalciferol. Other researchers should take note also of the fact that they used EFFECTIVE AMOUNTS 50,000iu/weekly for 12 weeks.

If in Kansas it takes roughly 7000iu/daily to get women with breast cancer to a level where their bodies have a reserve of D3 above their daily needs to deal with the inflammation and pain then it is probable that in the UK up to 10,000iu/daily may be required.

Skin Cancer/Sunscreen - the Dilemma